Not for resale without express authorization. Add a meaning Learn more about the word 'Idarucizumab', its origin, alternative forms, and usage from Wiktionary. The total cost for the reversal of a major bleeding was. idaru-cizum-ab Add phonetic spelling Meanings for Idarucizumab Pradaxa reversing agent It is a drug that is sold under the brand name Praxbind and is a monoclonal antibody that is used as a reversal agent for dabigatran. Get quick delivery of medicines online from GNH India at the best price. Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199.įor Research Use Only. 2,400 (21 of total reversal cost of 11,450) for reversal of Dabigatran with idarucizumab. BUY Idarucizumab (Praxbind) 50 mg/mL by Boehringer Ingelheim Pharmaceuticals, Inc. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran. Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. 14 References edit a b c d e 'Andexxa- andexanet alfa injection, powder, lyophilized, for solution'. Two people may pay different prices for the same drug, depending on their insurance situation. Initial pricing (AWP) is 58,000 per reversal (800 mg bolus + 960 mg infusion, 3,300 per 100 mg vial) which is higher than reversal agents for other DOAC agents ( idarucizumab for use in dabigatran reversal is 4,200 per reversal). As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, especially when given to patients at increased risk (elderly, chronic kidney disease, concomitant NSAID or warfarin use, etc.). Prescription drug prices can be confusing. The cost of idarucizumab on the Canadian market had not been announced. Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. Idarucizumab is particularly interesting for reversing anticoagulation as quickly.
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